Korean
PRODUCTS
TOX SIL
Botulinum polypeptide-1 + PDO / PLGA material
As TOX SIL is a new concept of suture that combines Botulinum polypeptide-1 with PDO / PLGA suture,
it provides various effects of Botox effect and thread lifting by simple procedures.
PDO Monofilament
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PDO (polydioxanone) activates the skin cells at the insertion site, enhancing skin elasticity, removing flabby cheek and wrinkles, and gives lifting effects to the entire face.
PGLA Multifilament
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As PGLA is a biocompatible and biodegradable suture that is combined with poly glycolic acid (PGA) and polylactic acid (PLA), it has the advantage of implanting without surgical operation to induce regeneration of extracellular matrix such as collagen and elastin, and form selftissue.It can also be coated with a larger amount of Botulinum polypeptide-1 with Multifilament that combine PGA and PLA that is Monofilament.
Botulinum polypeptide-1 coated on suture through a microscope after sterilization can be clearly seen, and Botulinum polypeptide-1, which is heat-resistant, can have also similar effects to Botulinum Toxin after sterilization.
What is Botulinum polypeptide-1?
Botulinum Toxin destroys the protein SNAP-25 and blocks "SNARE Complex". As a result, it suppresses the release of the Acethylcholine vesicle and it paralyzes muscles, thereby improving wrinkles.
It is the Botulinum Light chain that acts on SNAP-25.
“Metheonyl r-Clostridium Botulinum polypeptide-1 Hexapeptide-40”", the world's first botulinum-derived component that has been peptidized theBotulinum light chain by the recombinant of DNA, is be permeable of skin cell and nerve cell using macromolecule transmission domain called MTD(Macromolecule Transmission Domain),
and it shows a similar effect with medical Botulinum Toxin injection.
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- MTD
(Macromolecule Transmission Domain) - cellular permeation basic structure by
macromolecular transmission domain
- MTD
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In vitro SNAP25 cleavage analysis
After reacting GST-SNAP25-EGFP and ATGC-BOLC for 4 hours at 37℃,
GST-SNAP25-EGFP cleavage was demonstrated to a dose-dependent manner of ATGC-BOLC.
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Cell-based analysis: Differentiated neuronal units Human cells
Cleavage of SNAP25 was demonstrated to the dose-dependent manner of ATGC-BOLC in differentiated neuronal unit human cells through Western blot. Cell permeability and
SNAP25 cleavage efficacy proved.
Cell permeability and SNAP25 cleavage efficacy proved.
ATGC-BOLC = Botulinum polypeptide-1
Cytotoxicity analysis
*No toxicity in neuronal unit human cell and keratinocyte.
Benefit
TOX SIL provides the efficacy of botulinum toxin treatment by suture inserting.
Unlike Toxin or filler injections, solid state sutures enable accurate procedure at the desired location.
It is possible to solve various skin problems as well as improving wrinkles from oral area to orbital area.
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Botox injected
- Toxin spreads at injection site.
- Unintended muscle paralysis
: Smile disturbance, flabby eyebrow
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VS
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Tox sil inserted
- Toxin does not spread.
- Effects correctly at the insertion site.
- Stronger effect on deep wrinkles.
- Simple and easy procedure.
Safety
In the case of botulinum toxin application, while causes serious side effects such as partial facial paralysis due to even slight diffusion of unintended muscle due toaccidental overpressure, the TOX SIL of solid state can be safely accessed.
Application
For the purpose of improving the skin trouble, insert with adjust the insertion position and amount of TOX SIL. It can be tightly tighten skin tissue by inserting from low concentration that is affected by osmotic pressure to high concentration direction.
