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Bolca Botulife Outperformer Dynamic Warming Up Gel & Relief and Recovery Lotion

Bolca Botulife Outperformer Dynamic Warming Up Gel. It is the first sports cream with a botulinum peptide component that uses scientifically proven skin penetration technology. Preventing injury, improving muscle efficiency, and improving training ability by warming up before exercise. It is absorbed quickly without stickiness and has no scent, so there is no repulsion even before and during exercise.
BENEFITS
  • It is a world-recognized patented technology (MTD skin penetration technology) material that is quickly absorbed without stickiness.
  • Preventing injury, improving muscle efficiency.
  • Improving training ability by warming up before exercise.
  • Has no scent, so there is no repulsion even before and during exercise. It helps warm up before exercise without artificial heat.
  • It helps calm skin and moisturizing.
KEY INGREDIENTS
Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40 Arginine, Centella Asiatica Extract, Allantoin, Pinus Sylvestris Leaf Oil Aloe Barbadensis Leaf Extract, Cucumber Fruit Extract
Bolca Botulife Outperformer Relief and Recovery Lotion. It is the first sports cream with a botulinum peptide component that uses scientifically proven skin penetration technology. It is quickly absorbed without stickiness to relieve muscle tension and pain. Along with this, it contains natural plant extracts, which gives a feeling of refreshment to stressed skin and increases skin moisture and elasticity.
BENEFITS
  • It is a world-recognized patented technology (MTD skin penetration technology) material that is absorbed into the muscles and fascia.
  • Giving tired body a refreshing feeling after exercise and helps recovery.
  • Relieving muscle tension and pain from exercise and stress.
  • Increases skin moisture and elasticity.
KEY INGREDIENTS
Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40, Menthol, Peppermint Leaf Extract, Pinus Sylvestris Leaf Oil, Shea Butter, Rosemary Extract ,Aloe Barbadensis Leaf Extract, Cucumber Fruit Extract
Key Ingredient Information. Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'. The key ingredient of BoLCA + BOTULIFE Outperformer is the ingredient of Botox, an anti-wrinkle injection. It is a substance derived from botulinum protein and is a recombinant protein made to allow skin penetration. Botulinum-Derivative Ingredient contains more than 95% of amino acids with type A of botulinum light chain and the remaining 5% of the core technology penetrates into the skin and acts on muscles and nerve cells.

Platform technology to improve transdermal delivery of
Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'

1st Action
Improved penetration of functional materials into stratum corneum and other skin layers by MTD.
2nd Action
Maximized efficacy through the delivery of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' into specific targets.
Modality of Intracellular delivery of MTD in 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40'
Intracellular penetration by MTD technology shows very high permeability and markedly less cellular damage than nano liposomes or general peptide component delivery technology (PTD)
MECHANISM ON NERVE CELL
  • SNARE Complex Exocitosis Acetylcholine Diffusion Binds to the Receptors on the Muscle
  • Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40
  • Approaching to the Cell
  • Direct Cell Membrane Translocation
  • Moves to the SNAP25
  • Cleaves SNAP25 by Light Chain Part
Permeation of keratinocytes
FITC-bound 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' protein was applied to keratinocyte skin cells, and it was confirmed that the protein was observed within 1 to 6 hours. This result shows that 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' can penetrate the skin.
Potential in human neuronal cell
Transfer ability in human nerve cellsFITC-coupled 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' protein was applied to differentiated SiMa cells (human neuroblastoma). After 3 hours, you can see that the protein is observed within the cells. These results show that 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' is delivered to human nerve cells, the most important destination of botulinum protein.
Transdermal Diffusion
Dermal spread‘ Performs a percutaneous diffusion test using Millipore's Strat-M membrane products. The amount of 'Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40' penetrating from 30 minutes to 24 hours is converted to a cumulative frequency using ELISA. You can see that it continues to infiltrate after 24 hours.
Reference. Botulinum toxin has been used for the treatment of many clinical disorders by producing temporary skeletal muscle relaxation. In pain management, botulinum toxin has demonstrated an analgesic effect by reducing muscular hyperactivity, but recent studies suggest this neurotoxin could have direct analgesic mechanisms different from its neuromuscular actions. At the moment, botulinum toxin is widely investigated and used in many painful diseases such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Further studies are needed to understand the exact analgesic mechanisms, efficacy and complications of botulinum toxin in chronic pain disorders. source : Application of Botulinum Toxin in Pain Management. Woo Seog Sim Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • Application of Botulinum Toxin in Pain Management.
    Woo Seog Sim Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University
    School of Medicine, Seoul, Korea.
    Botulinum toxin (BTX) is a pre-synaptic neuromuscular blocking agent that triggers chemical denervation by temporarily
    suppressing secretion of acetylcholine at motor nerve endings; therefore, BTX injections are useful for diseases with
    increased involuntary muscle activity or tension.
  • New therapeutic indications for botulinum toxins.
    Cordivari C. Misra VP. Catania S. Lees AJ. Mov Disord. 2004 Mar;19 Suppl 8:S157-61.
    Trials of BTX in painful conditions are ongoing mainly on refractory tension headache, migraine, and backache as well
    as dystonia-complex regional pain syndrome and myofascial pain with promising results. Recently, the fastest growing
    use for BTX toxin has been in the cosmetic applications.
  • Botulinum Toxin for the Treatment of Myofascial Pain Syndromes Involving the Neck and Back:
    A Review from a Clinical Perspective.
    José M. Climent,1 Ta-Shen Kuan,2 Pedro Fenollosa,3 and Francisco Martin-del-Rosario4
    There is evidence that botulinum toxin could be useful in specific myofascial regions such as piriformis syndrome.
    It could also be useful in patients with refractory MPS that has not responded to other myofascial injection therapies.
  • Botulinum toxin for myofascial pain syndromes in adults.
    Adriana Soares, Régis B Andriolo, Álvaro N Atallah, Edina MK da Silva
    Botulinum toxin is a protein produced by the bacterium Clostridium botulinum and is a potent neurotoxin that eventually
    inhibits muscle contractions. It is capable of selectively weakening painful muscles and interrupting the pain cycle.
  • A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of
    myofascial pain syndrome and pain from chronic muscle spasm.
    Porta M Pain. 2000 Mar;85(1-2):101-5.
    These results indicate the superior efficacy of BTX-A over conventional steroid treatment in patients suffering
    from MPS, when combined with appropriate physiotherapy.
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